Journal of Case Reports in Practice http://journalofcasereport.com/ojs/index.php/jrcp <p>Open-access <strong>Journal of Case Reports in Practice (JCRP)</strong> was established in early 2013 in order to publish scholarly important case reports.</p> <p>Importantly, this is a "fast-track" online journal that makes the final decision on received manuscripts (fast-track service) within 29 days. All accepted manuscripts will be published immediately after final amendments and approval.<br /><br />Our international team consists of highly motivated multinational scientists with solid knowledge and academic background who has been selected from the best investigators from several universities.<br /><br /><strong>Journal of Case Reports in Practice (JCRP)</strong> is quarterly, open access journal, publishing high-quality, peer reviewed case reports, case series, clinical images, case video and case audios from all areas of clinical, radiological and pathological (CRP) disciplines.</p> <p><br />We welcome all expert international scientists to join us as voluntary reviewer.</p> <p>JCRP applies the <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="alternate noopener">Creative Commons Attribution 4.0 (CC BY) International License</a> to the published works, which permits anyone to copy, distribute, or reuse without permission or fees, as long as the author(s) and original source are properly cited.</p> Journal of Case Reports in Practice en-US Journal of Case Reports in Practice 2322-5041 Hepatosplenic Sarcoidosis with Pulmonary Involvement: http://journalofcasereport.com/ojs/index.php/jrcp/article/view/120 <p>Sarcoidosis is a chronic multisystem granulomatous disease, manifesting in all ages and both sexes. African Americans have the highest incidence rate with a slight female predominance. Commonly the pulmonary system is affected and categorized into four stages. Extrapulmonary manifestations are rare with the liver and spleen being the most commonly affected viscera in the abdomen. Hepatic involvement is usually asymptomatic, with liver function tests (LFTs) being altered in some, commonly seen as elevated alkaline phosphatase. Imaging of the liver shows hepatomegaly and patchy infiltration with hypo-echoic areas. The spleen can also be affected, and although most are asymptomatic, occasional upper quadrant pain is reported, with similar radiological findings to that of the liver. Diagnosis of sarcoidosis requires matching radiological, clinical, and histological findings with the exclusion of similar disorders. Biopsies of affected organs show non-caseating granulomas and need to be differentiated from other granulomatous disorders. Treatment of sarcoidosis is based around the inflammatory nature of this disorder, with corticosteroids and methotrexate commonly being prescribed. In this case report, we examine the clinical presentation, histopathology, and treatment of a patient with hepatosplenic sarcoidosis, with a brief review of literature.</p> Zahra Mirfeizi Reza Nejad Shahrokh Abadi Copyright (c) 2022 Journal of Case Reports in Practice https://creativecommons.org/licenses/by-nc-nd/4.0 2022-08-08 2022-08-08 9 1