Hepatosplenic Sarcoidosis with Pulmonary Involvement: A Case Report on a Concomitant Extrapulmonary Site

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Zahra Mirfeizi
Reza Nejad Shahrokh Abadi

Abstract

Sarcoidosis is a chronic multisystem granulomatous disease, manifesting in all ages and both sexes. African Americans have the highest incidence rate with a slight female predominance. Commonly the pulmonary system is affected and categorized into four stages. Extrapulmonary manifestations are rare with the liver and spleen being the most commonly affected viscera in the abdomen. Hepatic involvement is usually asymptomatic, with liver function tests (LFTs) being altered in some, commonly seen as elevated alkaline phosphatase. Imaging of the liver shows hepatomegaly and patchy infiltration with hypo-echoic areas. The spleen can also be affected, and although most are asymptomatic, occasional upper quadrant pain is reported, with similar radiological findings to that of the liver. Diagnosis of sarcoidosis requires matching radiological, clinical, and histological findings with the exclusion of similar disorders. Biopsies of affected organs show non-caseating granulomas and need to be differentiated from other granulomatous disorders. Treatment of sarcoidosis is based around the inflammatory nature of this disorder, with corticosteroids and methotrexate commonly being prescribed. In this case report, we examine the clinical presentation, histopathology, and treatment of a patient with hepatosplenic sarcoidosis, with a brief review of literature.

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How to Cite
Mirfeizi, Z., & Nejad Shahrokh Abadi, R. (2022). Hepatosplenic Sarcoidosis with Pulmonary Involvement: : A Case Report on a Concomitant Extrapulmonary Site. Journal of Case Reports in Practice, 9(1). Retrieved from http://journalofcasereport.com/ojs/index.php/jrcp/article/view/120
Section
Case Report