Chronic hepatitis B and ozone therapy

Manuscript type : Brief Report | Article Date : 2015/02/20

  • Autors

    1. Turkmen Aygen
    2. Kesici Sevgi
    3. Elmali Nevzat
    4. Can Cangir Cihan
    5. Cakirguz Mensure
  • Abstract

    Ozone treatment has a direct lethal effect on virus during both acute and chronic phases of Hepatitis B disease. Various studies showed that ozone has %100 lethal effect on virus. Aim of this case report is to evaluate the possible role of ozone therapy in treatment of patients with chronic hepatitis B. A 23 years old female patient, HBsAg(+) and HBeAg(+) was detected. Ozone treatment was performed with major and minor autohemotherapy. By applying twice a week, 12 sessions of major autohemotherapy, 5 sessions of minor autohemotherapy were completed. The treatment after the 12th session was scheduled as once a week in the first month, once every two weeks in the second month and monthly after the 5th month. The patient was called for control once every two months after the 20th session when no clinical symptom was detected after a single major and minor autohemotherapy. We consider that treatment of medical ozone on patient with chronic hepatitis B is effective. But further evaluation and larger controlled trials are needed.
  • Description

    BRIEF REPORT

    Medical ozone has antibacterial, antifungal and antivirus effect. Ozone treatment has a direct lethal effect on virus during both acute and chronic phases of Hep-atitis B disease. It is suggested that medical ozone has an important role in the inactivation of the virus in Hepatitis C treatment. Various studies showed that ozone has %100 lethal effect on virus.1 The aim of this manuscript is to evaluate the possible role of ozone therapy in treatment of patients with chronic hepatitis B. A 23-year-old female patient whose father had HB-sAg(+), applied with lassitude and loss of appetite complaints 4 years ago and HBsAg(+) and HBeAg(+) were detected. Then chronic active B hepatitis was diagnosed following a liver biopsy. Patient with in-terferon treatment history was consulted for ozone treatment in our clinic after it was detected that PCR (positive polymerase chain reaction) HBV DNA was 23.000 IU/mL and serum alanine transaminase (ALT) was 65 U/L. Ozone treatment was planned with ma-jor (MAH) and minor (MiAH) autohemotherapy with ozone therapy unit (Humazone®, Bruchsal-Germany, year of production: 2009) (Fig. 1). Figure 1 By applying twice a week 12 sessions of MAH (2 -25 ug/mL, 100 mL), 5 sessions of MiAH (30 -35 ug/mL, 5 mL) were com-pleted. PCR control was performed after the 10th ses-sion. HBV DNA value was 1110 IU/mL, ALT was 35 U/L. The treatment after the 12th session was sched-uled as once a week in the first month, once every two weeks in the second month and monthly after the 5th month. The last HBV DNA value was 344,5 IU/mL, ALT value was 18 U/L. The patient was called for control once every two months after the 20th session when no clinical symptom was detected after a single MAH + MiAH session. There were no side effects with ozone treatment. Ozone therapy is claimed to be useful in treatment against hepatitis by improving the patient’s health and the healing time of the disease. Studies proved that ozone infused into donated blood samples can kill viruses. It does not do damage to healthy cells. Low-concentration ozone treatments (5–40 mg/mL) are used to stimulate the immune system and increase the antioxidant enzymes in the body. It has been found that lipid-enveloped viruses are the most sensitive.1 The possible mechanisms of antiviral action of ozone are denaturation of virions through direct con-tact with ozone, peplomer alteration, lipid and protein peroxide formation, activation of humoral and cell-mediated immunity, host-specific autovaccine creation, and anti-oxidant enzymes enhancement.1, 2 We performed ozone therapy to the patient due to these effects to hepatitis B virus. Few clinical studies are available in treatment of viral hepatitis.1, 3, 4. Betancourt et al.3, showed that ozone therapy is a suitable treatment against hepatitis, improving the patient’s health and the healing time of the disease with 80 patients suffering from A, B, C hepatitis. Gu et al.4 argued that basic treatment plus medical ozone treatment in chronic serious hepatitis improved survival and protected from hepatorenal syndrome and renal damage by significantly increasing renal blood flow and by decreasing plasma renin activity, angiotensin II and Aldesteron levels. Zaky et al.1 associated the nonexistence of HCV-RNA in serums of 25-45% chronic hepatitis C patients, with their ozone therapy. Significant decrease of HBV-DNA value in our patient after the 10th session and the detection of clinical recovery in her general condition shows the importance of ozone therapy applied in addition to the treatment in recent years in our country. In another study, comparative data are presented illustrating efficiency of the treatment of patients with chronic viral hepatitis by standard methods and combined with ozone therapy. Patients treated with the use of ozone exhibited better biochemical, virological, and functional characteristics compared with their counterparts managed by standard methods. The study suggests a higher efficiency of combined therapy.5 In addition, Jiao et al.6 performed a study with 42 patients with chronic hepatitis B. In this study, 22 patients treated with basic therapy were used as the control group. 20 patients treated with basic therapy plus ozone therapy were regarded as the treatment group. After the treatment, liver function of the treatment group and the control group had a significant improvement. The results showed that treatment of medical ozone in patients with chronic hepatitis B is effective. We consider that scientific background of this very low budget treatment will significantly grow with studies consisting of high number of cases. So further evaluation and larger controlled trials are needed.
    Figure 1 Ozone therapy unit

  • Reference

    1. 1.Zaky S, Kamel SE, Hassan MS, et al. Mahmoud H. Preliminary results of ozone therapy as possible treatment for patients with chronic hepatitis C. J Altern Complement Med. 2011 Mar; 17(3):259-63.
    2. 2.Bocci V. Ozone as a bioregulator: Pharmacology and toxicology of ozonetherapy today. J Biol Regul Homeost Agents 1996;10:31–53.
    3. 3.Betancourt Y., Toledo JM, Recio E., et al. Ozone therapy: A useful alternative on virulent hepatitis treatment. 2nd International Symposium on Ozone Application, Havana, Cuba, March 1997:24–26.
    4. 4.Gu XB, Yang XJ, Zhu HY, Xu YQ, Liu XY. Effect of medical ozone therapy on renal blood flow and renal function of patients with chronic severe hepatitis. Chin Med J (Engl). 2010 Sep; 123(18): 2510-3.
    5. 5.Neronov VA. Experience with the use of ozone for the treatment of chronic viral hepatitis. Vopr Kurortol Fizioter Lech Fiz Kult. 2009 Nov-Dec;(6):14-7.
    6. 6.Jiao XJ, Peng X. Clinilal study of medical ozone therapy in chronic hepatitis B of 20 patients. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Dec;22(6):484-5.